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植物神经节阻断药治疗高血压病虽具有降压作用强、奏效快的优点,但由于同时也阻断了副交感神经使胃肠运动減慢,消化液分泌減少、瞳孔扩大等因而产生便秘、口干、视物模糊、排尿困难等副作用,往往使治疗中断。1959年Maxwell等合成了交感神经末梢阻断药——胍乙啶(Guanethidine),能选择性地阻断交感神经末梢,而没有阻断副交感神经的不良作用,适用于各种类型高血压,有取代植物神经节阻断药的趋向,是目前一种较为理想的降压药物。我校附属第二医院于1962年11月以胍乙啶(瑞士Ciba药厂出品Ismelin)治疗部分高
Although autonomic blockade treatment of hypertension with antihypertensive effect and rapid effect, but also blocked the parasympathetic gastrointestinal motility slowed down, reduced secretion of digestive juice, pupil enlargement and other constipation, Dry mouth, blurred vision, dysuria and other side effects, often interrupted treatment. 1959 Maxwell synthesis of sympathetic nerve terminal blocker - guanethidine (Guanethidine), can selectively block the sympathetic nerve endings, without blocking the adverse effects of parasympathetic, suitable for all types of hypertension, there Substitution of autonomic ganglion to block the trend is now a more ideal antihypertensive drugs. Second Affiliated Hospital of our school in November 1962 with guanethidine (Ciba Pharmaceutical Factory, Switzerland produced Ismelin) part of the treatment of high