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目的 :观察托吡酯加用治疗多种类型癫痫发作的临床疗效。方法 :2 18名癫痫病人 ,均为用过各种抗癫痫药物治疗效果不佳的难治性癫痫 ;采用逐渐加量法 ,加量期 8wk ,托吡酯开始剂量为 2 5mg·d- 1,目标剂量为 2 0 0mg·d- 1,观察 12wk后进入延长期。结果 :治疗后 ,2 6例病人 (12 .3% )发作完全消失 ,5 9例 (2 8.0 % )发作减少≥ 75 % ;10 7例(5 0 .7% )发作减少≥ 5 0 %～ <75 % ;19例(9 .0 % )无效。 5例 (2 .3% )因严重不良反应而中断治疗。 2例失访 (原因不明 )。结论 :托吡酯是一种非常有效的新型抗癫痫药物 ,值得临床推广使用
Objective: To observe the clinical effect of topiramate combined with multiple types of seizures. Methods: Twenty-eight patients with epilepsy were treated with various antiepileptic drugs. The incremental dose was 8wk, the dose of topiramate was 25mg · d-1, Dose of 200 mg · d-1, observed after 12wk into the extension. Results: After the treatment, 26 patients (12.3%) had complete disappearance of seizures, 59 (28.0%) seizures were reduced by 75% or more, and 107 (57.0%) seizures were reduced by 50% <75%; 19 cases (9.0%) were invalid. Five patients (2.3%) discontinued treatment due to serious adverse reactions. 2 cases lost (unexplained). Conclusion: Topiramate is a very effective new anti-epileptic drug, which is worthy of clinical promotion