硝苯吡啶为细胞膜慢通道阻滞剂,近年来发现它对肝、胆、胰疾病有较好的疗效,现总结如下。 1、肝硬化门脉高压: 肝硬化的纤维组织在很大程度上为具有平滑肌细胞和成纤维细胞特性的收缩细胞所组成,这些肌成纤维细胞常位于门静脉和肝静脉细小分枝周围的疤痕组织内,当它们收缩时,可使肝内血流阻力增大,可能在门脉高压的形成中起重要作用。业已证实,Ca++能介导肌成纤维细胞的收缩,而硝苯吡啶能放松和消除这种收缩。李氏等报告11例 Nifedipine is a slow-channel blocker of cell membrane, found in recent years it has a good effect on liver, gallbladder, pancreatic disease are summarized as follows. 1. Cirrhosis of the portal hypertension: Cirrhosis of the fibrous tissue is largely composed of contractile cells characterized by smooth muscle cells and fibroblasts, these myofibroblasts are often located in the small branches of the portal vein and hepatic vein scar around Tissues, when they contract, can increase intrahepatic flow resistance and may play an important role in the formation of portal hypertension. Ca ++ has been shown to mediate myofibroblast contraction, whereas nifedipine relaxes and eliminates this contraction. Lee et al reported 11 cases