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目的:探讨白细胞介素(IL)-6、IL-17和转化生长因子(TGF)-β在腺性膀胱炎(CG)组织中的表达及其在CG发病及进展中的作用。方法:将15例正常膀胱黏膜定为对照(A)组,43例未复发CG定为治愈(B)组,13例复发和癌变的CG定为进展(C)组;检测3组IL-6、IL-17和TGF-β的表达情况,并分析这些因子与CG发病及进展的相关性。结果:A组、B组及C组IL-6、IL-17和TGF-β的阳性表达率差异均有统计学意义(P<0.01)。3种因子与CG发病(rs分别为0.431、0.545、0.354,P<0.05)和进展(rs分别为0.426、0.333、0.288,P<0.05)呈正相关;IL-17分别与IL-6、TGF-β呈正相关(rs分别为0.997、0.961,P<0.05)。结论:IL-6、IL-17和TGF-β可能在CG的发病及进展中起重要作用。
Objective: To investigate the expression of interleukin (IL) -6, IL-17 and transforming growth factor (TGF) -β in glandular cystitis (CG) and its role in the pathogenesis and progression of CG. Methods: Fifteen cases of normal bladder mucosa were divided into control group (A), 43 cases of non-recurrent CG as a cure group (B), 13 cases of recurrent and cancerous CG as progression group (C) , IL-17 and TGF-β, and to analyze the correlation between these factors and the onset and progression of CG. Results: The positive rates of IL-6, IL-17 and TGF-β in group A, group B and group C were significantly different (P <0.01). The three factors were positively correlated with the incidence of CG (rs 0.431,0.545,0.354, P <0.05) and progression (rs 0.426,0.333,0.288, P <0.05 respectively) β (rs = 0.997,0.961, P <0.05). Conclusion: IL-6, IL-17 and TGF-β may play an important role in the pathogenesis and progression of CG.