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目的 研究慢性肺源性心脏病患者经中西医结合治疗后的血小板功能的变化及临床疗效。方法 将 44例肺心病患者采用随机分成 2组 ,中西医结合治疗组 2 3例 ,对照组 2 1例。分别在治疗前后采用流式细胞仪、比浊法分别检测各组血小板膜α 颗粒膜蛋白 (GMP - 140 ,即CD6 2p+)、血小板溶酶体完整膜蛋白 (CD6 3+)、糖蛋白Ⅱb(GPⅡb ,即CD41+)、血小板聚集率(PAgt)水平 ,并进行临床综合疗效评价。结果 2组慢性肺心病患者CD6 2p+、CD6 3+、CD41+、PAgt治疗前组间比较无统计学差异 ,在治疗后有统计学差异 ,其临床综合疗效有显著差异。结论 中西医结合治疗慢性肺心病患者 ,可抑制血小板活化功能 ,其临床疗效优于对照组
Objective To study the changes of platelet function and clinical curative effect in patients with chronic cor pulmonale treated by integrated Chinese and western medicine. Methods Forty-four patients with pulmonary heart disease were randomly divided into two groups, 23 in the combination of TCM and WM, and 21 in the control group. The levels of α - membrane protein (GMP - 140, CD6 2p +), platelet lysosome intact membrane protein (CD6 3+) and glycoprotein Ⅱb (Ⅱ) in each group were detected by flow cytometry and turbidimetry respectively before and after treatment. GP Ⅱ b, CD41 +), platelet aggregation rate (PAgt) levels, and evaluate the clinical efficacy. Results There was no significant difference between the two groups before treatment of CD6 2p +, CD6 3 +, CD41 + and PAgt in the two groups of patients with chronic cor pulmonale. There was a significant difference after treatment, and the clinical effect was significantly different. Conclusion Integrative Medicine in patients with chronic pulmonary heart disease can inhibit platelet activation, the clinical efficacy is better than the control group