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测定46例急性脑血栓病人,18例TIA病人及31例脑动脉硬化病人血清丙二醛(MDA)的水平。结果表明,急性期脑血栓病人血清MDA水平高于健康对照组,两者差别有极显著性(P<0.01);TIA病人血清MDA稍高于健康对照组;脑血栓组病人血清MDA水平高于TIA组及脑动脉硬化组,差异均有显著性(P<0.05)。结果提示,脂质过氧化作用在脑血栓的形成中起到一定的作用,脑血栓形成以后MDA水平上升,进一步加重脑损伤。
The serum levels of malondialdehyde (MDA) in 46 patients with acute cerebral thrombosis, 18 TIA patients and 31 patients with cerebral arteriosclerosis were measured. The results showed that serum MDA levels in patients with acute cerebral thrombosis were significantly higher than those in healthy controls (P <0.01), serum MDA in TIA patients was slightly higher than that in healthy controls, serum MDA levels in patients with cerebral thrombosis were significantly higher than those in healthy controls TIA group and cerebral arteriosclerosis group, the difference was significant (P <0.05). The results suggest that lipid peroxidation plays a role in the formation of cerebral thrombosis, MDA levels increased after cerebral thrombosis, further aggravating brain injury.