Pre-pubertal periodontitis (PPP) is a rare and rapidly progressive form of early onset periodontitis resulting in premature tooth loss of primary and permanent dentitions. Mutations in cathepsin C (CTSC) gene have been found in patients with pre-pubertal periodontitis and Papillon-Lefevre syndrome which also characterized with severe periodontitis and palmoplantar hyperkera-tosis.1-3　To date, more than 40 mutations of CTSC gene have been identified in ethnically diverse people worldwide.4　However, there is no such genetic analysis in China. In the present study, we report the mutation analysis of a Chinese patient with PPP.