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作者应用ＭＩＰＳ－１型自动图像分析仪，检测２５例小肝癌细胞核形态学参数及ＤＮＡ含量。结果发现，随着小肝癌细胞分化程度的减低（Ｅｄｍｏｎｄｓｏｎ分级Ⅰ～Ⅲ级），肿瘤细胞核面积、最大直径、积分光密度呈增高趋势，术后复发率逐渐增高（０％、３８．９％、８０％）。复发组肝癌细胞核周长、核最大直径、核积分光密度及ＤＮＡ指数均明显高于未复发组，分别为２５．８４±２．０７比２４．０５±２．７８，８．３８±０．８７比７．７３±０．８１，７．９７±１．８１比５．６５±２．０１，３．０６±１．１１比２．０１±０．５２（Ｐ＜０．０５～０．００５）。结果表明，细胞核增大程度是反映肝癌细胞分化度与恶性度的有效指标。Ｅｄｍｏｎｄｓｏｎ分级对判定肝癌细胞分化程度及预后具有临床实际意义，但核形态参数与ＤＮＡ指数比较，后者在判定分化程度及复发、预后方面更具明显优势。
The author applied a MIPS-1 automatic image analyzer to detect nuclear morphological parameters and DNA content of 25 small hepatocellular carcinoma cells. The results showed that with the decrease in differentiation of small hepatocellular carcinoma cells (Edmondson grades I-III), the nuclear area, maximum diameter, and integrated optical density of the tumors showed an upward trend, and the postoperative recurrence rate gradually increased (0%, 38.9%, 80%). The nuclear perimeter, nuclear maximum diameter, nuclear integral optical density and DNA index of hepatoma cells in relapse group were significantly higher than those in non-recurrence group, which were 25.84±2.07, 24.05±2.78, and 8.38±0, respectively. 87 to 7.73±0.81, 7.97±1.81 to 5.65±2.01, and 3.06±1.11 to 2.01±0.52 (P<0.05 to 0. 005). The results showed that the degree of nuclear enlargement was an effective indicator reflecting the degree of differentiation and malignancy of hepatoma cells. Edmondson grading has clinical significance for judging the differentiation and prognosis of hepatoma cells, but the nuclear morphological parameters are compared with the DNA index. The latter has obvious advantages in judging the degree of differentiation, recurrence, and prognosis.