1　病例报告　　患者男,6 1岁,因腹泻自服黄连素4片,每日3次,3d后感胃脘部疼痛不适,伴烧灼感,无反酸、呕吐,继续服药。其次日下午出现双下肢足底及内踝侧皮肤发红、肿胀、刺痛感,双足不敢着地,行走受限,即来院治疗。患者既往对磺胺药过敏。入院查体:体温36 5℃,脉搏80 /min , 1 case report Male, 6 1 years old, due to diarrhea self-serving berberine 4 tablets 3 times a day, 3 days after the Department of Stomach pain, discomfort, with burning sensation, no acid reflux, vomiting, continue to take medicine. The next afternoon there are two lower extremity plantar and medial malleolus side of the skin redness, swelling, tingling, feet can not land, limited walking, that is to hospital. Patients had previous allergies to sulfa drugs. Admission examination: body temperature 36 5 ℃, pulse 80 / min,