论文部分内容阅读
目的:建立湿疹软膏中薄荷脑与冰片的含量测定方法。方法:采用气相色谱法,用乙酸乙酯提取薄荷脑、冰片,以水杨酸甲酯为内标物,使用PEG-20M色谱柱,用氢火焰离子检测器检测。结果:通过方法学考察,薄荷脑在0.05012~0.5012 mg/m L范围内呈良好的线性关系,平均回收率为99.60%(n=9)。冰片在0.06032~0.6032 mg/m L范围内呈良好的线性关系,平均加样回收率为99.24%(n=9)。结论:该方法简便、准确、重复性好、精密度高。可用于湿疹软膏的工艺研究。
Objective: To establish a method for the determination of menthol and borneol in eczema ointment. Methods: Gas chromatography was used to extract menthol and borneol with ethyl acetate. Methyl salicylate was used as internal standard, and PEG-20M column was used for detection with hydrogen flame ionization detector. Results: Through methodological study, menthol showed a good linear relationship in the range of 0.05012 ~ 0.5012 mg / m L with an average recovery rate of 99.60% (n = 9). There was a good linear relationship between borneol content in the range of 0.06032 ~ 0.6032 mg / m L, and the average recovery was 99.24% (n = 9). Conclusion: The method is simple, accurate, reproducible and precise. Can be used for eczema ointment process research.