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目的根据半四左方对实验性胃溃疡大鼠胃粘膜组织EGF和TGF-α的影响,观察半四左方的抗溃疡作用并探讨其作用机制。方法采用束缚水浸应激法和醋酸法,建立大鼠胃溃疡模型。经半四左方干预后,测定大鼠溃疡指数、溃疡面积、胃粘膜组织EGF和TGF-α含量。结果半四左方可显著降低胃溃疡大鼠溃疡指数和溃疡面积(P<0.01),可显著提高胃溃疡大鼠胃粘膜组织EGF和TGF-α水平(P<0.01)。结论提高大鼠胃粘膜组织EGF和TGF-α含量水平可能是半四左方抗胃溃疡的作用机制之一。
Objective To observe the effect of “He Si Left” on EGF and TGF-α in gastric mucosa of rats with experimental gastric ulcer and to observe the anti-ulcer effect of “He Si Left” and to explore its mechanism. Methods Binding immersion stress method and acetic acid method were used to establish gastric ulcer model in rats. After the intervention by the semi-four left, ulcer index, ulcer area, gastric mucosal EGF and TGF-αlevels were determined. Results Hezuo Left could significantly reduce ulcer index and ulcer area in gastric ulcer rats (P <0.01), and could significantly increase the levels of EGF and TGF-α in gastric mucosa of gastric ulcer rats (P <0.01). Conclusion Increasing the levels of EGF and TGF-α in gastric mucosa of rats may be one of the mechanisms of the effect of semi-four-left gastric ulcer.