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目的:探讨门静脉插管滴注5-氟尿嘧啶化疗在大肠癌术后肝转移中的预防效果。方法:对32例大肠癌患者在根治切除肿瘤后(术前、术中均未发现临床肝转移),实施门静脉插管滴注5-氟尿嘧啶预防性化疗1周;观察其术后5年内肝转移的发生率。结果:预防性化疗组5年内肝转移的发生率为12.5%,对照组25.0%,两组相比较P<0.01,差异有极显著性。结论:大肠癌术后门静脉插管滴注5-氟尿嘧啶预防性化疗可预防肝转移,中西医结合治疗更有助于术后机体的恢复。
Objective: To investigate the preventive effect of portal vein catheter infusion of 5-fluorouracil chemotherapy on liver metastasis after colorectal cancer. Methods: Thirty-two patients with colorectal cancer undergoing radical excision of the tumor (no clinical liver metastases were found before and during surgery) were treated with portal vein catheter instillation of 5-fluorouracil for 1 week; liver metastases were observed within 5 years after operation. The incidence. Results: The incidence of hepatic metastasis in the prophylactic chemotherapy group was 12.5% within 5 years and 25.0% in the control group. The difference between the two groups was P<0.01. The difference was extremely significant. Conclusion: Intravenous infusion of 5-fluorouracil in the portal vein can prevent liver metastasis after operation of colorectal cancer. Integrative Chinese and Western medicine treatment is more helpful to the recovery of the body after operation.