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目的探讨人纤溶酶原激活剂抑制物２型（ＰＡＩ－２）基因在胃癌组织中表达与分布的作用。方法采用ＡＢＣ方法检测发生和未发生淋巴结转移的胃癌组织中ＰＡＩ－２、ｕＰＡ和ＰＡＩ１的表达，各３０例。结果ＰＡＩ－２主要在平滑肌细胞中表达，ｕ－ＰＡ和ＰＡＩ－１主要在肿瘤细胞中表达（Ｐ＜０．０１）。ＰＡＩ－２在胃癌组织中的分布以及表达程度与肿瘤的淋巴结转移相关。肿瘤的淋巴结转移与肿瘤细胞是否表达ＰＡＩ－２无关（Ｐ＞０．０５）。但在有ＰＡＩ－２表达的病例中，肿瘤的淋巴结转移却与肿瘤细胞ＰＡＩ－２的表达程度呈正相关，而与平滑肌细胞ＰＡＩ－２的表达程度呈负相关（Ｐ＜０．０１）。结论ＰＡＩ－２在胃癌组织中的表达与抑制肿瘤细胞的浸润与转移无明显相关
Objective To investigate the expression and distribution of human plasminogen activator inhibitor type 2 (PAI-2) gene in gastric cancer. Methods ABC method was used to detect the expression of PAI-2, u PA and PAI 1 in gastric cancer tissues with and without lymph node metastasis, 30 cases each. Results PAI-2 was mainly expressed in smooth muscle cells, and u-PA and PAI-1 were mainly expressed in tumor cells (P<0.01). The distribution and expression of PAI-2 in gastric cancer are related to lymph node metastasis. The lymph node metastasis of the tumor was not related to whether the tumor cells expressed PAI-2 (P>0.05). However, in patients with PAI-2 expression, the lymph node metastasis was positively correlated with the expression of PAI-2 in tumor cells, but negatively correlated with the expression of PAI-2 in smooth muscle cells (P<0.01). Conclusion The expression of PAI-2 in gastric cancer is not significantly related to the inhibition of invasion and metastasis of tumor cells.