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目的：以ｂ－ＦＧＦ表达为指标，研究与肝细胞癌侵袭性有关的分子机理．方法：应用免疫组化方法研究ｂ－ＦＧＦ在７０例肝细胞癌组织中的表达及其与肝细胞癌侵袭性的关系．结果：ｂ－ＦＧＦ在肝细胞癌组织中表达阳性率为６５．７１％，侵袭性肝癌高于非侵袭性肝癌（Ｐ＜０．０５），不同大小肝癌及不同包膜状况肝癌，其ｂ－ＦＧＦ表达无显著差异，ｂ－ＦＧＦ表达与原发性肝癌的病理分级．ＨＢｓＡｇ和ＡＦＰ无明显关系．结论：ｂ－ＦＧＦ表达可能与肝细胞癌的侵袭性有关．
Objective: To study the molecular mechanism of hepatocellular carcinoma invasiveness with b-FGF expression as an index. METHODS: Immunohistochemistry was used to study the expression of b-FGF in 70 cases of hepatocellular carcinoma and its relationship with invasiveness of hepatocellular carcinoma. Results: The positive expression rate of b-FGF in hepatocellular carcinoma was 65.71%, invasive hepatocellular carcinoma was higher than that of non-invasive hepatocellular carcinoma (P<0.05). Hepatocellular carcinoma with different size hepatocellular carcinoma and different envelope status was b- No significant difference in FGF expression, b-FGF expression and pathological grade of primary liver cancer. There is no obvious relationship between HBsAg and AFP. Conclusion: The expression of b-FGF may be related to the invasiveness of hepatocellular carcinoma.