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目的研究亚低温治疗重症手足口病并发中枢性发热的临床疗效。方法选取2010年6月~2013年6月本院收治的47例重症手足口病并发中枢性发热患者为研究对象,将其随机地分为对照组和治疗组,对照组23例给予常规药物治疗,治疗组24例给予亚低温治疗,对比两组患者体温变化、实验室指标以及治疗时间。结果对照组治疗后,体温由(38.6±0.5)℃下降至(36.7±0.3)℃,治疗时间为(4.0±1.1)h;治疗组,体温由(38.7±0.3)℃下降至(36.8±0.4)℃,治疗时间为(2.0±1.3)h,两组对比,治疗时间存在明显差异,具有统计学意义(P<0.05);两组实验室指标对比无明显差异,不具有统计学意义(P>0.05)。结论亚低温治疗重症手足口病并发中枢性发热安全可靠,疗效确切,治疗时间短,因此,值得临床推广和应用。
Objective To study the clinical efficacy of mild hypothermia in treating severe HFMD complicated by central fever. Methods From June 2010 to June 2013, 47 cases of severe HFMD complicated with central febrile disease admitted to our hospital were selected as study subjects, randomly divided into control group and treatment group, and 23 patients in control group received routine drug treatment , 24 patients in the treatment group were treated with mild hypothermia. The changes of body temperature, laboratory indexes and treatment time were compared between the two groups. Results After treatment, the body temperature decreased from (38.6 ± 0.5) ℃ to (36.7 ± 0.3) ℃ and the duration of treatment was (4.0 ± 1.1) h. After treatment, the body temperature decreased from (38.7 ± 0.3) ℃ to (36.8 ± 0.4) ), The treatment time was (2.0 ± 1.3) h, there was significant difference between the two groups in the treatment time, with statistical significance (P <0.05); there was no significant difference between the two groups in laboratory indexes > 0.05). Conclusion Mild hypothermia in the treatment of severe hand-foot-mouth disease complicated by central fever is safe and reliable, the curative effect is definite and the treatment time is short. Therefore, it is worthy of clinical promotion and application.