甘露醇与山梨醇系同分异构体,两者均可作渗透性利尿剂。20%甘露醇注射液系过饱和溶液,冬季贮藏期间易析出结晶,为解决结晶问题,可利用山梨醇在水中溶解度大的特点与甘露醇配伍,制成复方甘露醇(10%山梨醇+15%甘露醇)注射液。本品渗透压为1632mOs/kg·H_2O,大于20%甘露醇的渗透压1324mOs/kg·H_2O,故本品作为渗透性利尿剂能收到同样的效果。 Mannitol and sorbitol isomers, both can be used as osmotic diuretics. 20% mannitol solution supersaturated solution, easy to precipitate crystallization during winter storage, in order to solve the problem of crystallization, the solubility of sorbitol can be used in water compatibility with mannitol to make compound mannitol (10% sorbitol +15 % Mannitol) injection. This product osmotic pressure of 1632mOs / kg · H_2O, greater than 20% mannitol osmotic pressure of 1324mOs / kg · H_2O, so the product as a permeable diuretic can receive the same effect.