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目的:建立并提高蓝翘解毒口服液质量标准。方法:采用TLC法对连翘、山豆根和知母进行定性鉴别,HPLC法对板蓝根进行定性鉴别,采用HPLC法测定连翘中连翘苷的含量。结果:连翘、山豆根、知母的薄层色谱斑点清晰,阴性无干扰。HPLC鉴定板蓝根的中的(R,S)-告依春,分离度良好,阴性无干扰,专属性强。连翘中连翘苷的含量测定方法专属性良好,阴性无干扰。结论:建立的质量标准专属性强,方法重复性好,可作为改进蓝翘解毒口服液的质量控制标准。
Objective: To establish and improve the Quality Standard of Blue Alice Detoxification Oral Liquid. Methods: Qualitative identification of Forsythia suspense, Sophora flavescens and Anemarrhena asphodeloides by TLC method were carried out. The content of Forsythin in Forsythia suspensa was identified by HPLC. Results: Forsythia, Fructus solanum, Zhimu thin layer chromatography spots clear, negative non-interference. HPLC identification of Radix (R, S) - reported by the spring, good resolution, negative non-interference, specificity and strong. Forsythia in forsythin content determination method of good specificity, negative non-interference. Conclusion: The established quality standards are highly specific and reproducible, which can be used as a quality control standard for improving the oral liquid of Lan Qiao Jie Du.