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CDKs活性的改变将介导肿瘤相关的细胞周期缺陷。失去调控的CDKs诱导无限制的增殖和基因及染色体的不稳定性。根据通常的模式,哺乳动物CDKs对细胞周期的进程很关键,以至于阻碍CDK活性的化疗不能选择性的靶定肿瘤细胞。遗传学资料表明CDK1对细胞周期是必需的,而且分裂间期CDKs对特殊细胞的增殖是非常重要的。最新研究表明肿瘤细胞的增殖也需要特殊的分裂间期CDKs。因此,选择性的抑制CDK有利于人类某种肿瘤的治疗。
Changes in CDKs activity will mediate tumor-associated cell cycle defects. Loss of regulated CDKs induces unlimited proliferation and genetic and chromosomal instability. According to the usual paradigm, mammalian CDKs are critical to the cell cycle progression so that chemotherapy that blocks CDK activity can not selectively target tumor cells. Genetics data indicate that CDK1 is essential for the cell cycle and that interphase CDKs are important for the proliferation of specific cells. Recent research shows that the proliferation of tumor cells also requires special interphase CDKs. Therefore, the selective inhibition of CDK is beneficial for the treatment of certain human tumors.