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目的:观察扶正解毒中药与微波凝固联合治疗肝癌的增效解毒作用。方法:设治疗组21例:采用扶正解毒中药内服、参麦针、清开灵针剂静滴,配合微波对肝肿块凝固治疗;对照组20例:在微波对肝肿块凝固治疗基础上,配用肌苷保肝药治疗。观察两组治疗前后的症状、体症、KPS评分、肿瘤标志物、肝功能、血常规、瘤灶变化、生存期等。结果:治疗组症状改善有效率75.21%,KPS评分提高率23.1%,高于对照组的52.79%和7.01%(P<0.05)。治疗组在降低r-GT,AKP,转氨酶和胆红素方面疗效比对照组好;在降低AFP和CEA方面两组相似且疗效显著,升高血浆白蛋白两组均无明显效果。治疗后两组血象均有改善,治疗组更明显。两组肿块缩小率(20.5%比20%)和1、2年生存率(38.1%,23.8%,比50.0%,10.0%)无显著差异(P>0.05)。结论:扶正解毒中药联合微波凝固治疗肝癌,可以起到明显的增效解毒作用,提高患者的生活质量。
Objective: To observe the synergistic detoxification effect of Fuzheng detoxification traditional Chinese medicine combined with microwave coagulation in the treatment of liver cancer. Methods: 21 cases in the treatment group were treated with Fuzheng detoxification traditional Chinese medicine orally, Shenmai injection and Qingkailing injection, and coagulation therapy with microwave on the liver mass. In the control group, 20 cases were treated with microwave coagulation therapy of liver mass Inosine hepatoprotective treatment. The symptoms, physical symptoms, KPS scores, tumor markers, liver function, blood routine, tumor changes and survival were observed before and after treatment in both groups. Results: The effective rate of improvement in the treatment group was 75.21%, the improvement rate of KPS score was 23.1%, which was higher than that of the control group (52.79% and 7.01%, P <0.05). The treatment group was better than the control group in reducing r-GT, AKP, aminotransferase and bilirubin; the two groups were similar in reducing AFP and CEA, and the treatment effect was remarkable. There was no obvious effect in raising plasma albumin in both groups. Hemogram of both groups improved after treatment, the treatment group was more obvious. There was no significant difference between the two groups (20.5% vs. 20%) and the one and two year survival rates (38.1%, 23.8%, 50.0%, 10.0%) (P> 0.05). Conclusion: Fuzheng detoxification combined with microwave coagulation treatment of liver cancer, can play a significant synergistic detoxification, improve patient quality of life.