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重症肌无力是由自身抗体引起的一种自身免疫性疾病。目前已知的致病性抗体包括抗乙酰胆碱受体抗体，抗肌肉特异性酪氨酸激酶抗体以及抗低密度脂蛋白受体相关蛋白4抗体。不同抗体类型的重症肌无力在疾病发生、发展过程中的临床特征及诊治特点也不尽相同。文中就近年来抗肌肉特异性酪氨酸激酶抗体阳性重症肌无力发病机制、临床特征及诊疗特点的相关研究进展进行综述，旨在促进神经内科医师对该病的了解和掌握。“,”Myasthenia gravis is an autoimmune disease caused by autoantibodies. The currently known pathogenic antibodies include anti-acetylcholine receptor antibody, anti-muscle-specific tyrosine kinase antibody and anti-low density lipoprotein receptor associated protein 4 antibody. However, myasthenia gravis with different type antibodies are partly different in the pathogenesis, disease progression, clinical characteristics, treatment and prognosis. This article reviews the recent progress in the pathogenesis, clinical features, treatment strategies of anti-muscle-specific tyrosine kinase antibody positive myasthenia gravis, in order to promote the understanding and mastery of this disease by neurologists.