目的检测FMR-1基因敲除小鼠的脑组织中Ficolin-B的表达情况。方法取14天龄FMR-1基因敲除小鼠与14天龄C57小鼠脑组织中皮质、杏仁核、海马进行western-blot。结果 14天龄FMR-1基因敲除小鼠与14天龄C57小鼠脑组织中皮质、杏仁核、海马中均表达Ficolon-B蛋白,FMR-1基因敲除小鼠与C57对照小鼠中的相应脑组织的表达差异不大,但两组小鼠其大脑皮质、杏仁核和海马组织之间的表达差异较为明显,皮质表达量最大,海马表达量最低。结论 Ficolin-B有可能影响FXS的进程。 Objective To detect the expression of Ficolin-B in the brain of FMR-1 knockout mice. Methods Western-blot was performed on cortex, amygdala and hippocampus in 14-day-old FMR-1 knockout mice and 14-day-old C57 mice. Results The Ficolon-B protein was expressed in cortex, amygdala and hippocampus in 14-day-old FMR-1 knockout mice and 14-day-old C57 mice. In FMR-1 knockout mice and C57 control mice, Of the corresponding brain tissue expression differences, but the two groups of mice cortex, amygdala and hippocampus tissue expression differences between the more obvious, the highest cortex expression, the lowest expression of the hippocampus. Conclusion Ficolin-B may affect the progression of FXS.