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目的:采用双盲法观察咪达唑仑在颌面部手术麻醉前应用的效果,并与常规术前药地西泮的镇静效果比较。方法:颌面部择期手术病人40例,ASA分级Ⅰ-Ⅲ级,随机分成两组:A组予咪达唑仑0.08mg/kg,B组予地西泮0.2mg/kg,均于手术前30min肌肉注射,观察麻醉后药效果。结果:两组病人在镇静效果上有极显著性差异（P<0.01）,抗焦虑上有显著性差异（P<0.05）。结论:咪达唑仑于颌面部手术麻醉前用药,疗效可靠,使用安全,能够达到满意的镇静、抗焦虑的临床效果。
OBJECTIVE: To observe the effect of midazolam anesthesia before and after maxillofacial surgery by double-blind method and to compare the sedation effect of diazepam with conventional preoperative medicine. Methods: 40 patients undergoing elective maxillofacial surgery and ASA grading Ⅰ-Ⅲ were randomly divided into two groups: group A received midazolam 0.08mg / kg, group B received diazepam 0.2mg / kg, both before operation 30min intramuscular injection, observed after anesthesia drug effect. Results: The two groups of patients had a significant difference in the sedation effect (P <0.01), and there was a significant difference in anti-anxiety (P <0.05). Conclusion: Midazolam is used before anesthesia in maxillofacial surgery, which has reliable curative effect and safe use, and can achieve satisfactory clinical effect of sedation and anti anxiety.