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目的分析2008年2月深圳市发现的流行性脑脊髓膜炎病例进行病原学研究资料,为流行性脑脊髓膜炎的诊治及控制提供科学依据。方法参照GB16884-1997《流行性脑脊髓膜炎诊断标准和处理原则》的方法,进行常规分离培养、APINH生化鉴定卡鉴定、血清学凝集试验、乳胶凝集试验、实时荧光PCR试验,同时对菌株进行药敏试验。结果经实验研究证实,临床收集疑似流行性脑脊髓膜炎病例为B群脑膜炎奈瑟氏菌引起的流行性脑脊髓膜炎病例,菌株对头孢噻肟、头孢曲松、美罗培南、阿齐霉素、咪诺环素、氯霉素、利福平、氨苄西林、青霉素敏感,对环丙沙星、甲氧苄啶/磺胺甲唑耐药。结论B群脑膜炎奈瑟氏菌引起的流行性脑脊髓膜炎病例少见,提示应加强流脑的病原学监测和脑膜炎奈瑟氏菌的耐药性监测。
Objective To analyze the epidemiological data of cases of epidemic meningococcal disease in Shenzhen City in February 2008 and provide a scientific basis for the diagnosis, treatment and control of epidemic meningococcal meningitis. Methods According to GB16884-1997 “Diagnostic Criteria and Treatment Principles of Epidemic Meningitis”, routine isolation and culture, APINH biochemical identification card identification, serological agglutination test, latex agglutination test and real-time fluorescence PCR test were carried out. At the same time, drug allergy testing. Results The experimental study confirmed that the clinical collection of suspected meningococcal meningitis cases is Neisseria meningitides group B epidemic meningitis cases, the strains of cefotaxime, ceftriaxone, Meropenem, Azi Mycotoxin, minocycline, chloramphenicol, rifampin, ampicillin, penicillin sensitive, ciprofloxacin, trimethoprim / sulfamethoxazole resistance. CONCLUSION: Neisseria meningitidis group B has rare cases of epidemic meningococcal meningitis, suggesting that etiological monitoring of meningococcal meningitis should be strengthened and drug resistance of Neisseria meningitidis be monitored.