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目的探讨经皮瘤内注射~(32)P玻璃微球(~(32)P-GMS)对肝癌瘤组织的影响及其最佳剂量。方法建立24只兔VX2肝癌模型,分为A、B、C、D 4组并分别经皮瘤内注射37、74、111和148个放射性强度单位(MBq)的~(32)P-GMS,7、14和21 d后分批处死实验兔并取注药部位肿瘤组织,在光镜和电镜下观察其病理变化。结果注射~(32)P-GMS剂量与肿瘤细胞的放射性损害相关。A、B组不能完全杀死癌组织；C组肿瘤细胞几乎完全消失,纤维结缔组织对瘤灶形成完整的包绕；D组未见存活的肿瘤组织,但见正常肝组织亦被累及。结论经皮瘤内注射适量的~(32)P-GMS可以最大限度地杀伤瘤组织,本实验显示111 MBg为最佳剂量,对于阻止肝癌转移具有重要意义。
Objective To investigate the effect of percutaneous intratumoral injection of ~ (32) P glass microspheres (~ (32) P-GMS) on hepatocellular carcinoma and the optimal dosage. Methods Twenty-four VX2 hepatocellular carcinoma (HCC) models were established and divided into groups A, B, C, and D and treated with 37, 34, 111 and 148 radioactive intensity units (MBq) After 7, 14 and 21 days, the experimental rabbits were sacrificed in batches and the tumor tissues were injected. The pathological changes were observed under light and electron microscopes. Results The dose of ~ (32) P-GMS injected was related to the radioactive damage of tumor cells. A, B group can not completely kill the cancer tissue; C group of tumor cells almost completely disappear, fibrous connective tissue formed complete neoplasia; D group did not survive tumor tissue, but see also normal liver tissue is also involved. Conclusion Intraperitoneal injection of the appropriate amount of 32 P-GMS can kill tumor tissue to the maximum extent. This experiment shows that 111 MBg is the best dose, which is of great significance for preventing the metastasis of liver cancer.