论文部分内容阅读
血凝素(HA)是流感病毒的主要表面糖蛋白,具有强免疫原性,它有五个抗原位点:A～E,其中位点A通常用作外源多肽的插入点。1型人类免疫缺陷症病毒(HIV-1)的包膜蛋白gp120/gp160虽能诱导机体产生中和抗体,但抗体寿命短,并且完整的gp120/gp160疫苗可诱导促进感染的抗体。进一步研究发现包膜蛋白的第三超变区(V3)是一个由二硫键连接的约35个氨基酸的环,含有主要中和抗原决定簇,及细胞毒性T淋巴细胞和辅助性T细胞的识别位点。
Hemagglutinin (HA) is the major surface glycoprotein of influenza virus and has strong immunogenicity. It has five antigenic sites: A ~ E, of which site A is usually used as an insertion point for foreign polypeptides. Although the envelope protein gp120 / gp160 of human immunodeficiency virus type 1 (HIV-1) can induce the body to produce neutralizing antibodies, it has a short antibody life span, and the intact gp120 / gp160 vaccine can induce the infection-promoting antibodies. Further studies revealed that the third hypervariable region of the envelope protein (V3) is a disulfide-linked, approximately 35 amino acid loop containing major neutralizing epitopes, as well as cytotoxic T lymphocytes and helper T cells Recognition sites.