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目的:探讨天麻素注射液联合地塞米松治疗突发性耳聋的疗效及对患者血液流变学和听力值的影响。方法:将2018年8月至2020年3月在太原钢铁（集团）有限公司总医院耳鼻喉科就诊的突发性耳聋患者80例按照随机数字表法分为对照组、治疗组各40例。对照组采用鼓室注射地塞米松治疗。治疗组在对照组治疗基础上，联合天麻素注射液治疗。比较两组治疗总有效率；检测两组患者0.5 kHz、1.0 kHz、2 kHz、4 kHz的听阈值，比较患者治疗前后血浆黏度、低切全血黏度、纤维蛋白原、红细胞变形指数；记录两组患者在治疗期间药物相关不良反应的发生情况。结果:治疗组总有效率为92.50%（37/40），对照组为75.00%（30/40），两组差异有统计学意义（χn 2=4.401，n P<0.05）；两组治疗后0.5 kHz、1.0 kHz、2 kHz、4 kHz的听阈值均显著降低（均n P<0.001）；治疗后，治疗组0.5kHz、1.0 kHz、2 kHz、4 kHz的听阈值分别为（42.71±7.06）dB、（44.01±9.35）dB、（48.06±11.37）dB、（52.40±14.26）dB，对照组分别为（50.14±8.09）dB、（53.70±10.46）dB、（55.10±13.47）dB、（59.26±15.77）dB，两组比较，差异均有统计学意义（n t=4.376、4.368、2.526、2.267，均n P<0.05）。两组治疗后的血浆黏度、低切全血黏度、纤维蛋白原均显著降低，红细胞变形指数等均显著升高（均n P<0.001）；治疗后，治疗组的血浆黏度、低切全血黏度、纤维蛋白原、红细胞变形指数分别为（1.68±0.39）mPa·s、（19.07±3.65）mPa·s、（3.11±0.58）g/L、（0.68±0.08），对照组分别为（2.01±0.41）mPa·s、（22.10±4.49）mPa·s、（3.89±0.75）g/L、（0.60±0.07），两组比较，差异均有统计学意义（n t=3.688、3.312、5.203、4.760，均n P0.05）。n 结论:天麻素注射液联合地塞米松治疗可提高突发性耳聋患者的疗效，有效改善患者的血液流变学和听力值，且安全性良好。“,”Objective:To investigate the efficacy of gastrodin injection combined with dexamethasone in the treatment of sudden deafness and its effect on hemorheology and hearing.Methods:Eighty patients with sudden deafness who received treatment in the Department of Otolaryngology, General Hospital of Taiyuan Iron and Steel (Group) Co., Ltd., from August 2018 to March 2020 were included in this study. These patients were randomly assigned to receive either intratympanic injection of dexamethasone (control group, n n = 40) or intratympanic injection of dexamethasone combined with gastrodin injection (treatment group, n n = 40). Total effective rate was compared between the two groups. The auditory threshold at 0.5, 1.0, 2 and 4 kHz was measured in each group. Before and after treatment, plasma viscosity, low shear whole blood viscosity, fibrinogen and erythrocyte deformability index were compared between the two groups. Drug-related adverse reactions were recorded in each group.n Results:Total effective rate in the treatment group was significantly higher than that in the control group [92.50% (37/40) n vs. 75.00% (30/40), n χ2 = 4.401, n P < 0.05]. After treatment, the auditory threshold at 0.5, 1.0, 2 and 4 kHz was significantly decreased compared with before treatment in each group (all n P < 0.001). After treatment, the auditory threshold at 0.5, 1.0, 2 and 4 kHz was (42.71 ± 7.06) dB, (44.01 ± 9.35) dB, (48.06 ± 11.37) dB and (52.40 ± 14.26) dB, respectively, in the treatment group and (50.14 ± 8.09) dB, (53.70 ± 10.46) dB, (55.10 ± 13.47) dB and (59.26 ± 15.77) dB respectively in the control group. There were significant differences between the two groups ( n t = 4.376, 4.368, 2.526 and 2.267, all n P < 0.05). After treatment, plasma viscosity, low shear whole blood viscosity and fibrinogen in each group were significantly decreased (all n P < 0.001). After treatment, erythrocyte deformability index in each group was significantly increased ( n P < 0.001). After treatment, plasma viscosity, low shear whole blood viscosity and fibrinogen were significantly decreased, and erythrocyte deformability index was significantly increased, compared with before treatment in each group. After treatment, plasma viscosity, low shear whole blood viscosity and fibrinogen, and erythrocyte deformability index were (1.68 ± 0.39) mPa · s, (19.07 ± 3.65) mPa · s, (3.11 ± 0.58) g/L, (0.68 ± 0.08), respectively in the treatment group, and (2.01 ± 0.41) mPa · s, (22.10 ± 4.49) mPa · s, (3.89 ± 0.75) g/L, (0.60 ± 0.07) respectively in the control group. There were significant differences in plasma viscosity, low shear whole blood viscosity and fibrinogen, and erythrocyte deformability index between the two groups ( n t = 3.688, 3.312, 5.203, 4.760, all n P 0.05).n Conclusion:Gastrodin injection combined with dexamethasone can enhance the curative effect on sudden deafness, effectively improve patient's hemorheology and hearing, and is highly safe.