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采用无创性高分辨超声技术，检测了１７例无症状的原发性高胆固醇血症患者和１７例血浆胆固醇水平正常的对照者在基础状态下，反应性充血及含服硝酸甘油后肱动脉的内径变化。结果显示，前者血流介导性肱动脉舒张较正常组明显减弱（５．９％±２．３％比１４．５％±３．４％，Ｐ＜０．００１）；血流介导性肱动脉舒张与血总胆固醇（ＴＣ）及低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）呈显著负相关（相关系数ｒ分别为－０．６４２及－０．６２３，Ｐ＜０．００１）；而两组对硝酸甘油的反应差异无显著性（２４．５％±４．３％比２３．０％±７．０％，Ｐ＝０．４９）。结果表明，原发性高胆固醇血症患者血管内皮依赖性舒张功能明显受损，ＬＤＬ－Ｃ升高是内皮依赖性舒张功能障碍主要的独立危险的因素。
Using non-invasive high-resolution ultrasound technology, 17 asymptomatic patients with primary hypercholesterolemia and 17 patients with normal plasma cholesterol levels were detected in the basal state, reactive hyperemia and bradykinesia with nitroglycerin Inner diameter changes. The results showed that the former diastolic blood flow-mediated brachial artery was significantly weaker than the normal group (5.9% ± 2.3% vs 14.5% ± 3.4%, P <0.001); blood flow-mediated Brachial artery diastolic and blood total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) was significantly negatively correlated (r = -0.642 and -0.623, P <0.001, respectively) There was no significant difference in response to nitroglycerin between groups (24.5% ± 4.3% vs 23.0% ± 7.0%, P = 0.49). The results showed that endothelium-dependent vasodilation was significantly impaired in patients with primary hypercholesterolemia, and elevated LDL-C was the major independent risk factor for endothelium-dependent dysthymia.