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目的探讨特发性性早熟(ICPP)患儿的垂体MRI表现及其与临床相关激素的关系,为临床诊断提供影像学依据。方法搜集49例确诊为ICPP的患儿(3.7~8.9岁),男4例,女45例,行垂体MRI检查,观察垂体上缘形态,测量腺垂体各径线并与正常对照组比较,分析其腺垂体各径线及其与卵泡刺激素(FSH)和黄体生成素(LH)激发峰值的关系。结果 49例ICPP患儿中,垂体上缘形态隆凸型45例(91.8%),平坦型4例(8.2%)。男性及女性患儿腺垂体冠状宽径、冠状高径、矢状高径、矢状前后径均比正常对照组增大(P<0.05),其中冠状高径、矢状高径比正常对照组明显增大(P<0.01)。ICPP患儿腺垂体冠状高径、矢状高径与FSH和LH激发峰值呈正相关(r=0.43,P<0.01;r=0.28,P<0.05)和(r=0.49,P<0.05;r=0.29,P<0.05)。结论 ICPP患儿腺垂体体积增大,垂体上缘形态以隆凸型多见,腺垂体冠状高径、矢状高径与FSH、LH激发峰值呈正相关。
Objective To investigate the MRI findings of pituitary in children with idiopathic precocious puberty (ICPP) and its relationship with clinically relevant hormones, and provide imaging evidence for clinical diagnosis. Methods 49 cases diagnosed as ICPP (ranged from 3.7 to 8.9 years) were collected. There were 4 males and 45 females. The pituitary MRI examination was performed to observe the shape of the upper edge of the pituitary gland. The diameters of the pituitary gland were measured and compared with those of the normal control group The diameter of the pituitary gland and its relationship with the follicle stimulating hormone (FSH) and luteinizing hormone (LH) excitation peak. Results In 49 cases of ICPP children, 45 cases (91.8%) were convex on the upper edge of pituitary and 4 cases (8.2%) were flat. The coronal width, coronal height, sagittal height and sagittal anteroposterior diameter of adenohypophysis in both males and females were significantly higher than those in normal controls (P <0.05). The coronal height, Significantly increased (P <0.01). There was a positive correlation between the height of pituitary gland and sagittal height of ICPP patients and the peak of FSH and LH (r = 0.43, P <0.01; r = 0.28, P <0.05) 0.29, P <0.05). Conclusions The pituitary gland of ICPP patients is enlarged, the shape of the upper edge of pituitary is more prominent, and the coronal and sagittal diameters of the pituitary gland are positively correlated with the peak values of FSH and LH.