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目的 :建立大鼠睾丸纤维化模型 ,为进一步研究睾丸纤维化的发病机制打下良好基础。 方法 :将Wistar大鼠分为正常组 (12只 )和模型组 (40只 ) ,采用制造自身免疫性睾丸炎的经典方法结合单侧睾丸内注射卡介苗 ,建立睾丸纤维化模型。 结果 :距第 1次免疫 80d时 ,自身免疫性睾丸炎的发生率为 10 0 % ,睾丸纤维化的发生率为11.1% ;距第 1次免疫 14 0d时 ,自身免疫性睾丸炎的发生率为 10 0 % ,睾丸纤维化的发生率为 81.5 %。 结论 :成功地建立了大鼠睾丸纤维化模型
Objective: To establish a rat model of testicular fibrosis, which laid a good foundation for further study on the pathogenesis of testicular fibrosis. Methods: Wistar rats were divided into normal group (n = 12) and model group (n = 40). The testicular fibrosis model was established by the classical method of autoimmune orchitis combined with unilateral testicular injection of BCG. Results: The incidence of autoimmune orchitis was 100% and testicular fibrosis was 11.1% 80 days after the first immunization. The incidence of autoimmune orchitis was significantly higher than that of the first immunization Was 100%, the incidence of testicular fibrosis was 81.5%. Conclusion: The rat model of testicular fibrosis was successfully established