目的　探讨男性去势手术对动脉粥样硬化相关生化指标的影响。　方法　对接受双侧睾丸切除手术的 30例前列腺癌患者 ,于术前、术后 1周及术后 1、4、8个月分别测定血清雄激素、前列腺特异抗原及与动脉粥样硬化有关的血脂、血糖、胰岛素和纤溶酶原激活物抑制剂 1、纤维蛋白肽A等生化指标 ,并进行分析。　结果　去势术后 1周 ,血睾酮、游离睾酮、前列腺特异抗原较术前显著降低。术后 1个月甘油三酯 [(1 8± 0 6 )mmol/L ,t=- 2 2 1,P <0 0 5 ]、空腹胰岛素及血糖、餐后 2h胰岛素及血糖开始较术前明显增高 ,差异有显著意义 ;而胰岛素敏感指数显著降低 (- 4 4± 0 4,t =3 72 ,P <0 0 1) ,差异有非常显著意义。术后 4个月 ,总胆固醇 [(6 6± 1 0 )mmol/L ,t=3 0 9]、低密度脂蛋白胆固醇 [(4 1± 0 9)mmol/L ,t =3 5 7]、纤溶酶原激活物抑制剂 1[(2 7 0 2± 5 98) μg/L ,t =2 33]、纤维蛋白肽A[(3 4± 1 7)nmol/L ,t =3 2 7]开始较术前明显增加 ;均P <0 0 5 ,差异有显著意义。脱氢表雄酮、性激素结合蛋白、高密度脂蛋白胆固醇、载脂蛋白α1及载脂蛋白 β、纤维蛋白原手术前后无明显改变。睾酮、游离睾酮与甘油三酯、总胆固醇、低密度脂蛋白胆固醇、纤溶酶原激活物抑制剂 1、纤维蛋白肽A、空腹胰岛 Objective To investigate the effects of male castration on the biochemical parameters related to atherosclerosis. Methods Thirty patients with prostate cancer underwent bilateral orchiectomy were enrolled in this study. Serum androgen, prostate-specific antigen and atherosclerosis were measured preoperatively, 1 week and 1, 4 and 8 months after operation Blood lipid, blood glucose, insulin and plasminogen activator inhibitor 1, fibrin peptide A and other biochemical indicators, and analysis. Results One week after castration, serum testosterone, free testosterone and prostate specific antigen were significantly lower than those before operation. One month after operation, triglyceride [(18 ± 0 6) mmol / L, t = -221, P <0.05), fasting insulin and blood glucose, 2h postprandial insulin and blood glucose began to be significantly higher than those before operation There was significant difference between the two groups. However, the insulin sensitivity index decreased significantly (-4 4 ± 0 4, t = 3 72, P 0 01). The difference was significant. At 4 months after operation, total cholesterol (6 6 ± 10 mmol / L, t = 300), low density lipoprotein cholesterol [(4 1 ± 0 9) mmol / L, t = , Plasminogen activator inhibitor 1 [(270 ± 5 98) μg / L, t = 2 33], fibrinopeptide A [(34 ± 17) nmol / L, t = 32 7] than before surgery significantly increased; all P <0 0 5, the difference was significant. Dehydroepiandrosterone, sex hormone binding protein, high density lipoprotein cholesterol, apolipoprotein α1 and apolipoprotein β, fibrinogen no significant change before and after surgery. Testosterone, Free Testosterone and Triglycerides, Total Cholesterol, Low Density Lipoprotein Cholesterol, Plasminogen Activator Inhibitor 1, Fibrin Peptide A, Fasting Islets