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人乳头瘤病毒(HPV)E7基因是目前公认的癌基因之一,其作用机制包括参与免疫逃逸、降低基因稳定性、DNA损伤、抑制凋亡和干扰细胞周期等,其中干扰细胞周期是E7重要的致细胞增殖机制。E7可以与视网膜母细胞瘤蛋白(pRb)家族和袋状蛋白(E2F)家族、细胞周期相关蛋白等多种细胞周期调控因子相互作用,从而引起细胞周期的失控,导致上皮细胞的过度增殖,甚至恶变。
Human papillomavirus (HPV) E7 gene is one of the currently accepted oncogenes and its mechanism of action includes immune escape, decreased gene stability, DNA damage, inhibition of apoptosis and interference with cell cycle and so on, of which interference with cell cycle is important for E7 The mechanism of cell proliferation. E7 interacts with a wide variety of cell cycle regulators, such as the retinoblastoma protein (pRb) family and the E2 protein (E2F) family and cell-cycle related proteins, resulting in loss of control of the cell cycle, resulting in excessive proliferation of epithelial cells and even Malignant change.