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目的探讨在生活方式改善的基础上用罗格列酮钠对空腹血糖受损(impaired fasting glucose,IFG)患者进行综合强化干预治疗的效果。方法将137例空腹血糖受损患者随机分成单纯生活方式干预组(健康教育+饮食+运动,n=68)和综合强化方式干预组(罗格列酮钠+运动+饮食,n=69),观察6个月。监测、对比、分析两组患者体质量指数(body mass index,BMI)、腰臀比(waist-hip ratio,WHR)、总胆固醇(total cholesterol,TC)、甘油三酯(total glycerin,TG)、低密度脂蛋白胆固醇(lowdensity lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、血尿酸(uric acid,UA)、空腹血糖(fasting plasma glucose,FPG)、餐后2h血糖(postprandial2hours plasma glucose,2hPG)、空腹胰岛素(fasting insulin,FINS),餐后2h胰岛素(2hours fasting insulin,2hINS),糖化血红蛋白(glycohemoglo-bin,HbA1c),并2h/NS进一步计算胰岛素分泌指数(insulin secretion index,HOMA-IS)和胰岛素抵抗指数(insulin resistance index,HOMA-IR)等指标。结果①综合强化干预组的患者,在干预治疗6个月后,TC、TG、LDL-C、UA、FPG、2hPG、FINS、HbA1c等明显下降(P<0·05);②生活方式干预组患者在坚持饮食控制和体育运动治疗6个月后,BMI、WHR、TC、TG、LDL-C、FPG、2hPG、FINS、HbA1c等有一定下降趋势(P>0·05)。结论对IFG患者在接受健康教育的基础上控制饮食、坚持运动,给予罗格列酮钠进行干预治疗是更有积极意义的。
OBJECTIVE: To investigate the effect of sodium goggles sodium on impaired fasting glucose (IFG) in patients undergoing intensive intensive intervention on the basis of lifestyle improvement. Methods One hundred and fourteen patients with impaired fasting glucose were randomly divided into intervention group (health education + diet + exercise, n = 68) and intervention group (rosiglitazone + exercise + diet, n = 69) Observe for 6 months. The body mass index (BMI), waist-hip ratio (WHR), total cholesterol (TC), total glycerin (TG) Low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), uric acid (UA), fasting plasma glucose (FPG) Postprandial 2hours plasma glucose (2hPG), fasting insulin (FINS), 2hours fasting insulin (2hINS), glycohemoglobin (HbA1c) and 2h / Insulin secretion index (HOMA-IS) and insulin resistance index (HOMA-IR) and other indicators. Results ①In the comprehensive intensive intervention group, the levels of TC, TG, LDL-C, UA, FPG, 2hPG, FINS and HbA1c decreased significantly after intervention for 6 months (P <0.05) After 6 months of diet control and physical exercise, the patients’ BMI, WHR, TC, TG, LDL-C, FPG, 2hPG, FINS and HbA1c all decreased to some extent (P> 0.05). Conclusion It is more positive for IFG patients to control their diet and insist on exercising on the basis of receiving health education and taking the intervention of sodium rosiglitazone.