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甲苯咪唑(Mebendazole)是七十年代初国外报道的具有广谱驱虫作用的新化合物。1975年由上海医药工业研究院合成,南京制药厂试制,同年医科院寄生虫病研究所等单位开始动物实验和毒性测定,接着又进行了临床观察。甲苯咪唑为淡黄色粉末,不溶于水,在普通溶媒中溶解度极低,易溶于甲酸、醋酸,可溶于苯醛。不吸湿,在空气中性质稳定。其分子式为甲基—5—苯酰苯甲咪唑—2—甲氨酸酯(C_(16)H_(13)N_3O_3)。
Mebendazole is a new compound with broad-spectrum repellent activity reported abroad in the early seventies. In 1975 by the Shanghai Institute of Pharmaceutical Industry synthesis, Nanjing Pharmaceutical Factory trial, the same year Institute of Parasitic Diseases Medical Institute and other units began animal experiments and toxicity determination, followed by a clinical observation. Mebendazole is a light yellow powder, insoluble in water, very low solubility in common solvents, soluble in formic acid, acetic acid, soluble in benzene aldehyde. Not hygroscopic, stable in the air. The molecular formula is methyl-5-benzoylbenzimidazole-2-carbamate (C_ (16) H_ (13) N_3O_3).