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胰腺癌具有极高的病死率,由于其激进的转移性质。解决基本的机制将是治疗的关键.胰腺癌由于具有较强的转移特性,而且在肿瘤产生早期缺乏有效的鉴别标志,因此是致死率很高的癌症类型之一。IL-17是一类细胞因子家族,包括6个成员(A,B,C,D,E,F),它是免疫反应中调控炎症发生的重要因素。IL17RB在许多器官组织表面具有表达,而且在肠道炎症反应中会出现IL17RB的上调。由于作者之前的研究发现IL17RB的缺失能够有效抑制乳腺癌的恶化,因此他们猜测IL-17B-IL-17RB也可能参
Pancreatic cancer has a very high case fatality due to its aggressive metastatic properties. To solve the basic mechanism will be the key to the treatment of pancreatic cancer because of its strong metastatic characteristics, but also in the early stages of tumor lack of effective identification markers, it is one of the types of cancer with high lethality. IL-17 is a family of cytokines consisting of 6 members (A, B, C, D, E, F) that are important factors in the regulation of inflammation in the immune response. IL17RB is expressed on the surface of many organ tissues and upregulates IL17RB in the intestinal inflammatory response. As the authors previous study found that IL17RB deletion can effectively inhibit the deterioration of breast cancer, they speculated that IL-17B-IL-17RB may also be a reference