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对发作期哮喘和慢性阻塞性肺疾病（ＣＯＰＤ）病人及正常人各２０例，检测外周血淋巴细胞（ＰＢＬＣｓ）培养上清液中白细胞介素－４（ＩＬ－４）含量、γ－干扰素（ＩＦＮ－γ）活性及其血清ＩｇＥ总浓度。结果表明，发作期哮喘组ＩＬ－４和ＩｇＥ均明显高于ＣＯＰＤ组及正常对照组（Ｐ＜０．００１）。ＩＬ－４和ＩＦＮ－γ及ＩＦＮ－γ与ＩｇＥ均呈负相关（ｒ＝－０．４８，－０．７５；Ｐ＜０．０５，０．００１）。而ＣＯＰＤ组与正常对照组之间的ＩＬ－４和ＩｇＥ无显著差异（Ｐ＞０．０５）。３组之间ＩＦＮ－γ活性亦无差异（Ｐ＞０．０５）。提示ＩＬ－４和ＩＦＮ－γ之间的相互平衡是哮喘发病过程中血清ＩｇＥ浓度调节的一种重要因素。
Twenty patients with asthma and chronic obstructive pulmonary disease (COPD) and 20 normal controls were included in this study. The content of interleukin-4 (IL-4) in supernatant of peripheral blood lymphocytes (PBLCs) (IFN-γ) activity and serum IgE total concentration. The results showed that the levels of IL-4 and IgE in asthma group were significantly higher than those in COPD group and normal control group (P <0.001). IL-4 and IFN-γ and IFN-γ and IgE were negatively correlated (r = -0.48, -0.75; P <0.05, 0.001). There was no significant difference in IL-4 and IgE between COPD group and normal control group (P> 0.05). There was no difference in IFN-γactivity among the three groups (P> 0.05). It is suggested that the balance between IL-4 and IFN-γ is an important factor in the regulation of serum IgE concentration during asthma pathogenesis.