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作者用体外琼脂集落形成的方法,检查一组骨髓增生性疾患和再生障碍性贫血患者骨髓中集落形成细胞(CFC)的浓度,并将各种疾病的骨髓 DNA 合成期的 CFC 比例作了比较,结果如下:在慢粒(CML)时平均有77CFC/2×10~5有核细胞,急变时平均为46CFC/2×10~6,缓解时为28CFC/2×10~5(正常位为34)。真性红细胞增多症(PV)时 CFC 增加,骨髓纤维化(MF)和红白血病时 CFC 减少,原发性血小板增多症时 CFC 不超过正常范围。在 CML 的集落中还可以见到在形态上正常的细胞分化,但 CML骨髓琼脂培养无急粒(AML)骨髓培养时所常见的细
The authors examined the concentration of colony forming cells (CFCs) in the bone marrow of a group of patients with myeloproliferative disorders and aplastic anemia by means of in vitro agar colony formation and compared the proportions of CFCs during bone marrow DNA synthesis for various diseases, The results were as follows: an average of 77 CFC / 2 × 10 5 nucleated cells in CML, an average 46 CFC / 2 × 10 6 for abrupt onset and 28 CFC / 2 × 10 5 for remission (normal 34 ). CFC increases in polycythemia vera (PV), CFC decreases in myelofibrosis (MF) and erythroleukemia, and CFC does not exceed the normal range in essential thrombocythemia. Morphologically normal cell differentiation can also be seen in the colonies of CML, but is common in CML bone marrow agar-agar-less acute granulocyte (AML) bone marrow cultures