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目的 研究口康含漱液的体外抑菌作用及临床疗效。方法 用琼脂稀释法测定口康含漱液对４９株口腔病菌的最低抑菌浓度，并对６０例急性白血病并口腔感染患者中４０例采用中药口康含漱液治疗、２０例采用口泰含漱液治疗。结果 ４９株口腔病菌中，２７株革兰氏阴性杆菌ＭＩＣ范围０．０３～１．０ｇ／ｍｌ，ＭＩＣ５０均为０．１２５ｇ／ｍｌ，ＭＩＣ９０为０．１２５～０．５０ｇ／ｍｌ；２１株革兰氏阳性球菌ＭＩＣ范围０．００８～０．５０ｇ／ｍｌ，ＭＩＣ５０ ０．０１５～０．１２５ｇ／ｍｌ，ＭＩＣ９０为０．０１５～０．５０ｇ／ｍｌ；１株白色念珠菌ＭＩＣ ０．０１５ｇ／ｍｌ。４０例急性白血病并口腔感染患者采用中药口康含漱液治愈率为８２．５％，总有效率９２．５％，较口泰对照组明显升高（Ｐ＜０．０１）。结论 口康含漱液对各类不同口腔病菌株均有抑菌作用；临床应用对急性白血病并口腔感染患者疗效明显优于口泰对照组，是一种较好的抗口腔感染的药物。
Objective To study the antibacterial effect and clinical efficacy of Kankang gargle in vitro. Methods Agar dilution method was used to determine the minimum inhibitory concentration (MIC) of Kankang gargle against 49 strains of oral bacteria. 40 cases of 60 cases of acute leukemia with oral infection were treated with traditional Chinese medicine Kankang gargle. 20 cases were treated with Kou Tai Gargle treatment. Results Among the 49 strains of oral bacteria, the MICs of 27 Gram-negative bacilli were 0.03-1.0 g / ml, the MIC50 was 0.125 g / ml and the MIC90 was 0.125-0.50 g / ml. 21 strains of leather The range of positive-point cercosporidium MIC is 0.008 ~ 0.50g / ml, MIC50 is 0.015 ~ 0.125g / ml, MIC90 is 0.015 ~ 0.50g / ml; . 40 cases of acute leukemia and oral infection patients with Chinese medicine Kankang gargle cure rate was 82.5%, the total effective rate was 92.5%, compared with the mouth Thai control group was significantly increased (P <0.01). Conclusions Kankang gargle has bacteriostasis to all kinds of oral cavity strains. The curative effect of clinical application on acute leukemia with oral infection is better than that of Koutai group, which is a good anti-oral infection medicine.