目的通过对前白蛋白（PA）的检测，了解其作为白血病及淋巴瘤对肝浸润的敏感指标。方法22例患儿在治疗前、后，和30例健康儿童对照组，通过免疫比浊法测定PA，并检测肝功能。结果22例治前患儿，10例（45．55％）PA下降（与对照组PA彦检验P＜0．005），5例白蛋白下降，2例谷丙、5例谷草转氨酶升高，2例总胆红素上升。治前PA异常的例数高于，肝功能值异常的例数。结论白血病和淋巴瘤对肝浸润时，PA的变化远较肝功能的变化为明显。 Objective To detect prealbumin (PA) as a sensitive index of leukemia and lymphoma on liver infiltration. Methods Twenty-two children with PA were measured by immunoturbidimetry before and after treatment, and 30 healthy children as controls. The liver function was measured. Results Among the 22 cases of pretreatment, 10 cases (45.55%) had decreased PA (P <0.005 with control group PA), 5 cases of albumin decreased, 2 cases of cereal and 5 cases of aspartate aminotransferase increased, 2 cases of total bilirubin increased. The number of abnormal PA cases before the treatment is higher than the number of abnormal liver function cases. Conclusion Leukemia and lymphoma on the liver infiltration, PA changes far more than the changes of liver function was obvious.