论文部分内容阅读
目的探讨充血性心力衰竭(CHF)患者血清白三烯B4(LTB4)水平与心功能的关系。方法对82例CHF患者按纽约心脏病学会心功能分级标准分为Ⅱ-Ⅳ级组,根据超声心动图检查结果,将入选者分为左心室正常组(左心室舒张末期容积≤55mm)和左心室增大组(左心室舒张末期容积≥55mm),用酶联免疫吸附法(ELISA法)检测血清LTB4含量,并与20例健康体检者进行对照。结果CHF组患者血清LTB4含量明显高于正常对照组(P<0.01),心功能Ⅲ、Ⅳ级的血清含量均高于Ⅱ级(P<0.01),左室增大组较左室正常组LTB4血清含量显著升高(P<0.01),LTB4的血清含量与CHF患者的严重程度及心脏左室增大均呈正相关(P<0.01)。结论LTB4是心功能受损的敏感指标,可以作为CHF相关的非创伤性指标之一。
Objective To investigate the relationship between serum leukotriene B4 (LTB4) levels and cardiac function in patients with congestive heart failure (CHF). Methods Eighty-two CHF patients were divided into grade Ⅱ-Ⅳ group according to the New York Heart Association grading standards. According to the results of echocardiography, the subjects were divided into normal left ventricular group (left ventricular end-diastolic volume ≤55mm) and left The ventricular enlargement group (left ventricular end-diastolic volume≥55mm), the content of serum LTB4 was detected by enzyme-linked immunosorbent assay (ELISA), and compared with 20 healthy subjects. Results The levels of serum LTB4 in CHF group were significantly higher than those in normal control group (P <0.01), and the serum levels of cardiac function Ⅲ and Ⅳ grade were higher than those in grade Ⅱ (P <0.01). The levels of LTB4 in left ventricular hypertrophy group were significantly higher than those in normal control group (P <0.01). The serum level of LTB4 was positively correlated with the severity of CHF and left ventricular hypertrophy (P <0.01). Conclusion LTB4 is a sensitive index of impaired cardiac function and can be used as one of the noninvasive indices related to CHF.