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目的 比较 E-钙粘附蛋白与相关蛋白α-连接蛋白在结肠腺癌的表达及在淋巴结转移中的作用。 方法 用 SP免疫组织化学方法检测 5 8例结肠癌中 E-钙粘附蛋白、α-连接蛋白的表达。 结果 结肠癌中 E-钙粘附蛋白、α-连接蛋白表达的减低比均为 5 8.6 %。 E-钙粘附蛋白的表达减低与淋巴结转移无关 (P>0 .0 5 ) ,而α-连接蛋白的表达减低与淋巴结转移显著相关 (P<0 .0 1)。 结论 α-连接蛋白减低表达与结肠癌淋巴结转移的关系较为密切。
Objective To compare the expression of E-cadherin and related protein α-catenin in colon adenocarcinoma and its role in lymph node metastasis. Methods SP immunohistochemistry was used to detect the expression of E-cadherin and α-catenin in 58 cases of colon cancer. Results The reduction ratio of E-cadherin and α-catenin expression in colon cancer was 58.6 %. The decreased expression of E-cadherin was not associated with lymph node metastasis (P>0.05), but the decreased expression of α-catenin was significantly associated with lymph node metastasis (P<0.01). Conclusion The decreased expression of α-catenin is closely related to the lymph node metastasis of colon cancer.