氢氯噻嗪是噻嗪类利尿剂 ,是最早被证实有预防血管病并发症和降低病死率的一线降压药[1] 。以往单用 ,剂量较大 ,出现许多不良反应。近年来 ,采用小剂量 (2 5ｍｇ/ｄ) 1次服药 ,既能保持 2 4ｈ的有效血药浓度 ,又能使不良反应减少 ,与其他降压药物联合应用还有较好的协同作用。 Hydrochlorothiazide is a thiazide diuretic, which is the earliest proven first-line antihypertensive drugs to prevent vascular complications and reduce mortality [1]. In the past alone, a larger dose, there are many adverse reactions. In recent years, the use of a small dose (25mg / d) taking a time, both to maintain effective blood concentration 24 hours, but also to reduce adverse reactions, combined with other antihypertensive drugs and there is a better synergy.