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精子形成是从精子细胞到精子的成熟过程,特征是染色质结构重建,基质蛋白发生多种改变。最显著的是组蛋白乙酰基化。精子形成中的染色质形态变化和组蛋白置换是由组蛋白H4.的超乙酰基化促发。组蛋白较低水平乙酰基化出现在组蛋白沉积阶段,而组蛋白高水平乙酰基化出现在发生组蛋白被取代的阶段。已在人Y染色体上分离出一组相关的基因CDY(Chromo Domain Y),CDY和小鼠Cayl的乙酰化转移酶(HAT)活性介导了精于形成过程中的H4超乙酰基化。
Spermatogenesis is the process of maturation from sperm cells to sperm and is characterized by chromatin structural remodeling and multiple changes in the matrix protein. The most significant is histone acetylation. Chromatin morphological changes in spermatogenesis and histone replacement by histone H4. Hyper-acetylation. Lower levels of histone acetylation appear in the histone deposition stage, while high levels of histone acetylation appear in the stage of occurrence of histone substitution. A group of related genes CDY (Chromo Domain Y), acetylated transferase (HAT) activity of CDY and mouse Cayl, have been isolated on the human Y chromosome mediating H4 hyperacetylation during formation.