论文部分内容阅读
目的比较长方案和改良超长方案两种GnRH-α降调节对子宫内膜异位症(endometriosis,EMs)合并不孕患者体外受精-胚胎移植(IVF-ET)助孕治疗结局的影响。方法回顾性分析2014年5月-2015年12月因EMs合并不孕在桂林市妇幼保健院生殖中心行首次治疗的IVF患者96例,按卵巢降调节方案分为:长方案(A组)59例,改良超长方案(B组)37例,比较两组患者以下指标:1一般资料情况:年龄、不孕年限、原发不孕周期数、继发不孕周期数、体重指数(BMI)、基础窦泡数(AFC)、基础卵泡刺激素(b FSH)、b E2、CA125;2控制性超排监测指标:Gn天数、Gn总量、h CG日E2、h CG日P、移植日EM;3ET结局监测指标:获卵数、受精率、种植率、可利用胚胎数、优胚数、移植胚胎数、妊娠率、多胎率、流产率、宫外孕率、取消移植周期率。结果 A、B两组在患者年龄、不孕年限、原发不孕周期数、继发不孕周期数、BMI、基础窦泡数、b FSH、b E2、CA125方面比较,均无统计学差异(P>0.05)。两组控制性超排监测指标,Gn天数、Gn总量、h CG日E2、h CG日P、移植日EM比较,均无统计学差异(P>0.05)。两组ET结局监测指标,获卵数、移植胚胎数、多胎率、流产率、宫外孕率、取消移植周期率均无统计学差异(P>0.05),B组与A组比较种植率有升高趋势(32.97%vs.27.97%),但差异无统计学意义(P>0.05),B组与A组在受精率、可利用胚胎数、优胚数、妊娠率比较比较有统计学差异(P<0.05)。结论子宫内膜异位症合并不孕患者行IVF-ET控制性超排的方案中,改良超长方案在受精率、可利用胚胎数、优胚数、妊娠率方面优于长方案,可以提高IVF-ET的成功率。
Objective To compare the effect of two GnRH-α down-regulation regimens with long-term regimen and long-term regimen on pregnancy-induced outcome of in vitro fertilization-embryo transfer (IVF-ET) in patients with endometriosis (EMs) and infertility. Methods A retrospective analysis of 96 cases of IVF patients treated with EMs combined with infertility in the Reproductive Center of Guilin Maternal and Child Health Hospital from May 2014 to December 2015 was divided into long protocol (group A) 59 Cases, improved long program (B group) 37 cases, the two groups of patients compared the following indicators: 1 General Information: Age, age of infertility, the number of primary infertility cycles, the number of secondary infertility cycles, body mass index (BMI) , Basic sinusoid (AFC), basal follicle-stimulating hormone (b FSH), b E2, CA125; 2 Controlled superovulation monitoring index: Gn days, Gn total, h CG day E2, h CG day P, EM; 3ET outcome monitoring indicators: the number of oocytes, fertilization rate, implantation rate, the number of available embryos, the number of embryos, the number of embryos transferred, pregnancy rate, multiple birth rate, miscarriage rate, ectopic pregnancy rate, abolish the cycle rate. Results There was no significant difference in age, duration of infertility, number of primary infertility, number of secondary infertility, BMI, basal sinusoid, b FSH, b E2 and CA125 between groups A and B (P> 0.05). There were no significant differences between the two groups (P> 0.05) in monitoring indicators of super control, Gn days, Gn total, h CG day E2, h CG day P, and EM on transplantation day. There was no significant difference in ET monitoring outcome, number of oocytes retrieved, number of embryos transferred, multiple birth rate, miscarriage rate, ectopic pregnancy rate and abolished graft cycle rate between the two groups (P> 0.05). The implantation rate of group B was significantly higher than that of group A (P> 0.05). There was a significant difference in fertilization rate, available embryos, excellent embryos and pregnancy rates between group B and group A (P <0.05) <0.05). Conclusion In the scheme of IVF-ET controlled superovulation in patients with endometriosis complicated with infertility, the improved overlong program can improve the fertilization rate, the number of available embryos, the number of excellent embryos and the pregnancy rate IVF-ET success rate.