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氧稳态的维持是细胞生命活动的基本前提。在进化过程中,细胞生物体获得了一系列机制以适应氧浓度变化,其中最重要的低氧信号传递因子是缺氧诱导因子-1(hypoxia-in- ducible factor-1,HIF-1)。HIF-1是广泛存在于哺乳动物和人
The maintenance of oxygen homeostasis is the basic premise of cell life activities. During evolution, a series of mechanisms have been developed for cellular organisms to adapt to changes in oxygen concentration. The most important hypoxia signaling molecule is hypoxia-inducible factor-1 (HIF-1). HIF-1 is widespread in mammals and humans