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精子头粒蛋白(acrosin)是一种主要存在于精子头部内膜的胰蛋白酶样的蛋白水解酶,与精子通过卵细胞透明带等受精过程有关。球形精子病时acrosin活性极低,即使精子浓度及运动性能正常也无法妊娠。受精时,精子获能最终引起顶体反应,但其过程首先是在顶体膜变成胞状化的同时,释放出透明质酸酶分解卵丘基质,随后顶体消失,acrosin暴露以溶解卵丘内侧的透明带,使精子容易通过。射出精子中的acrosin90%以无活性的acrosin前体状态存在,10%活性型acrosin也大部分与抑制剂结合成无活性的复合物。抑制剂来自附睾,防止acrosin的自然活化,控制精
The acrosin is a trypsin-like protease that is found mainly in the intima of the sperm head and is involved in fertilization of sperm through the zona pellucida. Spherical sperm acrosin disease activity is very low, even if the normal sperm concentration and exercise can not be normal pregnancy. When fertilized, sperm capacitation eventually causes acrosome reaction, but the process begins with the release of hyaluronidase to decompose the cumulus matrix, followed by the disappearance of the acrosin, acrosin exposure to dissolve the cumulus The inner zona pellucida, sperm easy to pass. 90% of the acrosin in the ejaculated sperm are present as inactive acrosin precursors, and most of the 10% active acrosin binds to the inhibitor as inactive complexes. Inhibitors come from the epididymis, prevent the natural activation of acrosin, control the essence