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目的完善吉林省结核病耐药监测网络,获得国际可比性的结核病耐利福平资料,评价现行结核病控制策略的效果。方法按照WHO/IUATLD的标准,采用100%诊断中心抽样方法,对所分离培养阳性菌株进行菌型鉴定及利福平(RFP)药物敏感性测试。结果收集到可供分析的结核分枝杆菌分离株1 772株,利福平的耐药率为16.70%;其中来自初治涂阳肺结核患者的菌株为1 175株(66.14%),利福平耐药率为10.47%;来自复治涂阳肺结核患者的菌株597株(33.69%),利福平耐药率为16.70%。结论吉林省结核病利福平耐药率高于全国平均水平,今后要进一步加强耐药结核病的防治工作。
Objective To improve the TB surveillance network in Jilin Province and obtain internationally comparable data on rifampin-resistant tuberculosis and evaluate the effectiveness of current TB control strategies. Methods According to the standard of WHO / IUATLD, the 100% diagnostic center sampling method was used to identify the strains that were isolated and cultured, and the drug susceptibility test of rifampicin (RFP) was performed. Results A total of 1 772 strains of Mycobacterium tuberculosis isolates were collected for analysis. The drug resistance rate of rifampicin was 16.70%. Among them, 1 175 strains (66.14%) were from smear-positive pulmonary tuberculosis patients, The resistance rate was 10.47%. 597 strains (33.69%) were from smear-positive pulmonary tuberculosis patients, and the resistant rate of rifampin was 16.70%. Conclusion The resistance rate of rifampin to tuberculosis in Jilin Province is higher than the national average level, and prevention and treatment of drug-resistant tuberculosis should be further strengthened in the future.