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目的研究ACEI类药物治疗老年原发性高血压的临床特点及效果,为临床提供指导。方法选择我院2011年2月至2012年2月原发性高血压患者186例,采用ACEI类药物治疗,疗程为6个月,观察治疗前后患者血压、血肌酐、24 h尿蛋白定量、血钾变化情况。结果 186例老年原发性高血压患者治疗前SBP与DBP分别为(160.7±23.3)mm Hg与(92.5±10.6)mm Hg,治疗后SBP与DBP分别为(121.6±14.7)mm Hg与(73.8±8.1)mm Hg,血压治疗后较治疗前明显下降,前后比较差异具有统计学意义P<0.05。治疗前与治疗后患者血肌酐、血钾无明显变化,差异无统计学意义P>0.05。治疗后24 h尿蛋白定量大大低于治疗前,差异具有统计学意义P<0.05。结论 ACEI不仅能控制血压,而且明显降低24 h尿蛋白定量,其治疗意义远远超出了控制患者血压本身,可延缓肾脏疾病的发生,
Objective To study the clinical features and effects of ACEI in the treatment of senile essential hypertension and provide guidance for clinical practice. Methods 186 patients with essential hypertension from February 2011 to February 2012 in our hospital were treated with ACEI drugs for 6 months. The changes of blood pressure, serum creatinine, 24 h urinary protein, Potassium changes. Results The SBP and DBP of 186 elderly patients with essential hypertension before treatment were (160.7 ± 23.3) mm Hg and (92.5 ± 10.6) mm Hg, respectively. The SBP and DBP were (121.6 ± 14.7) mm Hg and (73.8 ± 8.1) mm Hg, blood pressure decreased significantly after treatment, before and after the difference was statistically significant P <0.05. Before treatment and after treatment, serum creatinine, serum potassium did not change significantly, the difference was not statistically significant (P> 0.05). 24 h after treatment urinary protein was significantly lower than before treatment, the difference was statistically significant (P <0.05). Conclusion ACEI can not only control blood pressure, but also significantly reduce 24 h urinary protein, its therapeutic value far beyond the control of patients with blood pressure itself, can delay the occurrence of kidney disease,