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目的探讨QT间期离散度(QTd)和血清心肌肌钙蛋白(cTnI)在新生儿缺血缺氧性时心肌损伤的诊断价值,以及对预后的评价。方法将62例新生儿窒息患儿分为轻度(n=36)和重度两组(n=26),选择28例日龄、性别与窒息组比较差异无统计学意义的无窒息的新生儿为对照组,分别检测其cTnI,并在安静或睡眠情况下描记心电图,测定QTd值。结果窒息组cTnI、QTd较对照组明显升高(P<0.05),且重度窒息组与轻度窒息组比较差异有统计学意义(P<0.01)。结论血清中cTnI可作为新生儿缺血缺氧性心肌损害程度的敏感指标,且QTd比cTnI对心肌损害的判断具有特异性。
Objective To investigate the diagnostic value of QTd and cTnI in neonatal hypoxic-ischemic myocardial damage, and to evaluate the prognosis. Methods Sixty-two neonates with asphyxia were divided into mild (n = 36) and severe (n = 26), and 28 neonates without asphyxia As the control group, respectively, cTnI detection, and in the quiet or sleep electrocardiogram tracing, determination of QTd value. Results The levels of cTnI and QTd in asphyxia group were significantly higher than those in control group (P <0.05), and there was significant difference between severe asphyxia group and mild asphyxia group (P <0.01). Conclusion Serum cTnI can be used as a sensitive indicator of neonatal hypoxic-ischemic myocardial damage, and QTd is more specific than cTnI in determining myocardial damage.