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[目的]探讨浙江地区依赖还原型辅酶Ⅰ/Ⅱ醌氧化还原酶1(NQO1)基因多态性与膀胱癌易感性的关系。[方法]采用病例对照研究方法,应用相对的两对引物—聚合酶链反应技术(PCR-CTPP),对99例膀胱癌患者和100例非肿瘤患者的NQO1C609T基因型进行检测,并分析其与膀胱癌易感性的关系。[结果]NQO1C609T基因型分布频率在膀胱癌组和对照组之间的差异具有统计学意义(P<0.05),携带609TT基因型的个体罹患膀胱癌的风险是携带609CC基因型个体的2.448倍(95%CI为1.125~5.326)。NQO1C609T基因型分布频率在膀胱癌不同病理分级和临床分期之间的差异均无统计学意义(P>0.05)。[结论]NQO1C609T基因多态性可能与膀胱癌的易感性相关,携带NQO1609TT基因型的人群易患膀胱癌。
[Objective] To investigate the relationship between the polymorphism of the dependent coenzyme Ⅰ / Ⅱ quinone oxidoreductase 1 (NQO1) gene and susceptibility to bladder cancer in Zhejiang province. [Methods] The NQO1C609T genotypes of 99 cases of bladder cancer and 100 cases of non-tumor were detected by case-control study using two pairs of primers (PCR-CTPP) Bladder cancer susceptibility. [Results] The frequency of NQO1C609T genotype was significantly different between bladder cancer group and control group (P <0.05). The risk of bladder cancer in individuals with 609TT genotype was 2.448 times higher than that in individuals carrying 609CC genotype 95% CI 1.125 ~ 5.326). There was no significant difference in the frequency of NQO1C609T genotypes between different pathological grades and clinical stages of bladder cancer (P> 0.05). [Conclusion] The polymorphism of NQO1C609T may be associated with the susceptibility of bladder cancer. The population with NQO1609TT genotype is susceptible to bladder cancer.