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消炎痛(indomethacin)为吲哚类衍生物,系阿斯匹林的同类药,具有解热、镇痛、消炎、三者合一的作用特点,阿斯匹林的广泛应用已有近百年历史,该类药物自本世纪中叶以来又出现了不少新的合成药,如:吡唑酮类、灭酸类和吲哚类,其基本作用相似;Arrigoni-Martelli(1977)将此归属于非甾体类抗炎剂(NSAIA)的A类,也是典范的NSAIA。近十多年来,对此类药物的研究和应用又有很大进展,对其抗炎作用的认识和机理的了解也日益深入,这与同时期内对前列腺素(PG)的发现和致力研究中所获得的进展有关。 Vane(1971)首先阐明了NSAIA(如消炎痛、阿斯匹林)的作用主要是由于抑制PG的生物合成,并证实:通过抑制PG合成酶(环氧化酶),阻断了花生四烯酸(PG的前体)这一酶化作用阶段,使之不能合成PG。
Indomethacin, an indole derivatives, is a kind of aspirin similar drug, with antipyretic, analgesic, anti-inflammatory, one of the three characteristics of the role of aspirin has been widely used for nearly a hundred years of history Since the mid-century, many new synthetic drugs have emerged, such as pyrazolones, fenamic acids and indoles. Their basic functions are similar. Arrigoni-Martelli (1977) Class A steroidal anti-inflammatory drugs (NSAAs) are also exemplary NSAAs. In the recent ten years, great progress has been made in the research and application of such drugs, and their understanding of anti-inflammatory effects and their mechanisms have been deepened. This is in line with the discovery and dedication of prostaglandin (PG) during the same period The progress made in the study is relevant. Vane (1971) first clarified that the effect of NSAIA (such as indomethacin and aspirin) is mainly due to the inhibition of the biosynthesis of PG and confirms that by inhibiting PG synthetase (cyclooxygenase), arachidonic acid is blocked Acid (a precursor to PG), an enzyme phase that prevents PG synthesis.